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MALT lymphoma: from morphology to molecules

Nature Reviews Cancer volume 4, pages 644–653 (2004)Cite this article

Abstract

Hints that the growth of some lymphomas is stimulated by bacterial antigens and can be controlled by treatment with antibiotics first emerged in the 1970s. Subsequently, a specific type of B-cell lymphoma — mucosa-associated lymphoid tissue (MALT) lymphoma — was identified that is associated with bacterial infection and auto-antigen stimulation. This article chronicles the clinical, immunological and molecular developments in our knowledge of MALT lymphoma and the factors that contribute to its pathogenesis.

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Figure 1: Multistage development of gastric MALT lymphoma.
Figure 2: The different chromosomal translocations involved in MALT lymphoma affect a common molecular pathway.
Figure 3: BCL10 and MALT1 expression in MALT lymphoma with different chromosomal translocations.

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Acknowledgements

The work in the authors' laboratories was supported by research grants from The Leukaemia Research Fund.

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  1. the Department of Histopathology, Royal Free and University College Medical School, University College London, Rockefeller Building, University Street, London, WC1E 6JJ, UK

    Peter G. Isaacson

  2. the Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK

    Ming-Qing Du

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Correspondence to Peter G. Isaacson.

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The authors declare no competing financial interests.

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DATABASES

Cancer.gov

non-Hodgkin's lymphoma

Entrez Gene

API2

BCL10

CARD11

CD40

CD86

IL-2

MALT1

NEMO

TRAF6

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Isaacson, P., Du, MQ. MALT lymphoma: from morphology to molecules. Nat Rev Cancer 4, 644–653 (2004). https://doi.org/10.1038/nrc1409

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