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Histone macroH2A isoforms predict the risk of lung cancer recurrence

Oncogene volume 28, pages 3423–3428 (2009)Cite this article

Abstract

Lung cancer is the leading cause of cancer deaths. Despite optimal diagnosis and early treatment, many patients die of recurrent disease. There are no sufficiently useful biomarkers to predict the risk of tumor recurrence. Here, we show that expression of histone macroH2A1.1 and macroH2A2 predicts lung cancer recurrence, identifying these histone variants as a novel tool for an improved risk stratification of cancer patients. Moreover, macroH2A isoforms are highly expressed in cells undergoing senescence, a known antitumor mechanism, suggesting macroH2A1.1 may be a useful biomarker for senescent cells in tumors.

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Acknowledgements

We thank Dr Esther Herpel for lung cancer tissue microarrays. AGL is supported by the EMBL, the NoE The Epigenome and the Marie Curie RTN Chromatin Plasticity.

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Author notes

  1. J C Sporn and G Kustatscher: These authors contributed equally to this work.

Authors and Affiliations

  1. EMBL, Gene Expression Unit, Heidelberg, Germany

    J C Sporn, G Kustatscher & A G Ladurner

  2. Institut für Statistik, Ludwig-Maximilians-Universität München, München, Germany

    T Hothorn

  3. Spanish National Cancer Centre, c/Melchor Fernández Almagro, Madrid, Spain

    M Collado & M Serrano

  4. University of Heidelberg, Thoraxklinik, Heidelberg, Germany

    T Muley

  5. Department of Pathology, University of Heidelberg, Heidelberg, Germany

    P Schnabel

Authors
  1. J C Sporn
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  2. G Kustatscher
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  3. T Hothorn
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  4. M Collado
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  5. M Serrano
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  6. T Muley
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  7. P Schnabel
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  8. A G Ladurner
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Corresponding author

Correspondence to A G Ladurner.

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Supplementary Information accompanies the paper on the Oncogene website (http://www.nature.com/onc)

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Sporn, J., Kustatscher, G., Hothorn, T. et al. Histone macroH2A isoforms predict the risk of lung cancer recurrence. Oncogene 28, 3423–3428 (2009). https://doi.org/10.1038/onc.2009.26

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  • DOI: https://doi.org/10.1038/onc.2009.26

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