Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Genetic rearrangement of FOXP1 is predominantly detected in a subset of diffuse large B-cell lymphomas with extranodal presentation

Leukemia volume 20, pages 1300–1303 (2006)Cite this article

Recently, a novel recurrent translocation t(3;14)(p14.1;q32) was reported that results in the deregulated expression of the Forkhead Box P1 (FOXP1) gene by juxtaposing it to the immunoglobulin (Ig) H regulatory elements.1 In particular, Streubel et al.1 identified nine cases of low-grade marginal zone B-cell lymphomas (MZBL) of different localizations harboring this translocation. These results suggest that FOXP1 translocations may represent a novel recurrent genetic aberration in extranodal low-grade MZBL, besides the known t(11;18), t(14;18) and t(1;14). In two subsequent studies, FOXP1 translocations were also identified in two cases of diffuse large B-cell lymphoma (DLBCL) suggesting that this genetic event may not be confined to MZBL alone.2, 3

Here, we report on genetic alterations of the FOXP1 locus and FOXP1 protein expression in a large series of B-cell lymphomas. In total, 275 B-cell non-Hodgkin's lymphomas (B-NHL), referred to the Institute of Pathology, University of Würzburg, were included in this study (102 DLBCL, of which 49 were primary nodal and 53 extranodal tumors, 122 extranodal MZBL of MALT type from different localizations (nine cutaneous, 13 salivary gland, 50 pulmonary, 36 ocular adnexa, eight thyroid gland and six gastric tumors), 30 follicular lymphomas (FL) and 21 mantle cell lymphomas (MCL)). All samples were submitted to a standard immunostaining procedure and classified according to the World Health Organization (WHO) criteria.4

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Streubel B, Vinatzer U, Lamprecht A, Raderer M, Chott A . T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. Leukemia 2005; 19: 652–658.

    Article  CAS  Google Scholar 

  2. Wlodarska I, Veyt E, De Paepe P, Vandenberghe P, Nooijen P, Theate I et al. FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations. Leukemia 2005; 19: 1299–1305.

    Article  CAS  Google Scholar 

  3. Fenton JA, Schuuring E, Barrans SL, Banham AH, Rollinson SJ, Morgan GJ et al. t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma. Genes Chromosomes Cancer 2005; 45: 164–168.

    Article  Google Scholar 

  4. Jaffe ES, Harris NL, Stein H, Vardiman JW (eds). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001.

    Google Scholar 

  5. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 2004; 103: 275–282.

    Article  CAS  Google Scholar 

  6. Banham AH, Connors JM, Brown PJ, Cordell JL, Ott G, Sreenivasan G et al. Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma. Clin Cancer Res 2005; 11: 1065–1072.

    CAS  PubMed  Google Scholar 

  7. Barrans SL, Fenton JA, Banham A, Owen RG, Jack AS . Strong expression of FOXP1 identifies a distinct subset of diffuse large B-cell lymphoma (DLBCL) patients with poor outcome. Blood 2004; 104: 2933–2935.

    Article  CAS  Google Scholar 

  8. Bea S, Zettl A, Wright G, Salaverria I, Jehn P, Moreno V et al. Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction. Blood 2005; 106: 3183–3190.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank Dr PJ Brown, I Eichelbrönner and H Brűckner for their excellent technical assistance.

AHB is and RV was supported by the Leukemia Research Fund. EH, GO, AR and HKM-H are supported by the Deutsche Krebshilfe Grant 70-3173-Tr3. AR is supported by the Interdisciplinary Center for Clinical Research (IZKF) of the University of Würzburg.

Author information

Author notes

  1. A H Banham and G Ott: Both AHB and GO are the senior authors of this work.

Authors and Affiliations

  1. Institute of Pathology, University of Würzburg, Würzburg, Germany

    E Haralambieva, P Adam, T Katzenberger, J Kalla, S Höller, M Hartmann, A Rosenwald, A Greiner, H K Műller-Hermelink & G Ott

  2. Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK

    R Ventura & A H Banham

Authors
  1. E Haralambieva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P Adam
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R Ventura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T Katzenberger
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J Kalla
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S Höller
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M Hartmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A Rosenwald
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A Greiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. A H Banham
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. G Ott
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Haralambieva, E., Adam, P., Ventura, R. et al. Genetic rearrangement of FOXP1 is predominantly detected in a subset of diffuse large B-cell lymphomas with extranodal presentation. Leukemia 20, 1300–1303 (2006). https://doi.org/10.1038/sj.leu.2404244

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404244

This article is cited by

Search

Advanced search

Quick links