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MYC oncogenes and human neoplastic disease

Oncogene volume 18, pages 3004–3016 (1999)Cite this article

Abstract

c-myc, N-myc and L-myc are the three members of the myc oncoprotein family whose role in the pathogenesis of many human neoplastic diseases has received wide empirical support. In this review, we first summarize data, derived mainly from non-clinical studies, indicating that these oncoproteins actually serve quite different roles in vivo. This concept necessarily lies at the heart of the basis for the observation that the deregulated expression of each MYC gene is reproducibly associated with only certain naturally occurring malignancies in humans and that these genes are not interchangeable with respect to their aberrant functional consequences. We also review evidence implicating each of the above MYC genes in specific neoplastic diseases and have attempted to identify unresolved questions which deserve further basic or clinical investigation. We have made every attempt to review those diseases for which significant and confirmatory evidence, based on studies with primary tumor material, exists to implicate MYC members in their causation and/or progression.

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Acknowledgements

We apologize to our colleagues for omissions necessitated by the space constraints imposed on this review. This work was supported by NIH grant HL33741

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Authors and Affiliations

  1. Department of Pediatrics, Section of Hematology/Oncology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Chadd E Nesbit, Jean M Tersak & Edward V Prochownik

  2. The Department of Biochemistry and Molecular Genetics, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

    Edward V Prochownik

  3. The Program in Molecular Oncology, The Pittsburgh Cancer Institute, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

    Edward V Prochownik

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Nesbit, C., Tersak, J. & Prochownik, E. MYC oncogenes and human neoplastic disease. Oncogene 18, 3004–3016 (1999). https://doi.org/10.1038/sj.onc.1202746

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