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Roles of STAT3 defined by tissue-specific gene targeting

Oncogene volume 19, pages 2607–2611 (2000)Cite this article

Abstract

The physiological role of each individual STAT protein is now being examined through the study of ‘knockout’ (KO) mice, harboring a null allele for the particular gene. In contrast to other STATs deficient mice that are born alive, STAT3-deficient mice die during early embryogenesis. However, the role of STAT3 in adult tissues can be assessed by utilizing the Cre-loxP recombination system to ablate the gene in later life. Analyses of tissue-specific STAT3-deficient mice indicate that STAT3 plays a crucial role in a variety of biological functions including cell growth, suppression and induction of apoptosis, and cell motility.

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Acknowledgements

I thank Dr K Takeda for preparing the Figures, and T Aoki for excellent secretarial assistance. This work was in part supported by grants from the Ministry of Education of Japan.

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Authors and Affiliations

  1. Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,

    Shizuo Akira

  2. CREST of Japan Science and Technology Corporation, 3-1 Yamada-oka, Suita, 565-0871, Osaka, Japan

    Shizuo Akira

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Akira, S. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene 19, 2607–2611 (2000). https://doi.org/10.1038/sj.onc.1203478

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