Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

Basal-like breast cancer and the BRCA1 phenotype

Oncogene volume 25, pages 5846–5853 (2006)Cite this article

Abstract

Breast cancers arising in germline carriers of BRCA1 mutations have a characteristic phenotype that has been shown in many studies to differentiate BRCA1 tumours from sporadic tumours. Recently, it has become clear that the characteristic phenotype of BRCA1 tumours is due to expression of the basal-like phenotype. We review these phenotypes, the evidence for BRCA1 pathway dysfunction in sporadic basal-like cancers, and discuss the clinical significance of the basal-like phenotype for cancer genetics and treatment.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  • Abd El-Rehim DM, Ball G, Pinder SE, Rakha E, Paish C, Robertson JF et al. (2005). Int J Cancer 116: 340–350.

  • Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL et al. (2003). Am J Hum Genet 72: 1117–1130.

  • Armes JE, Egan AJ, Southey MC, Dite GS, McCredie MR, Giles GG et al. (1998). Cancer 83: 2335–2345.

  • Armes JE, Trute L, White D, Southey MC, Hammet F, Tesoriero A et al. (1999). Cancer Res 59: 2011–2017.

  • Arnes JB, Brunet JS, Stefansson I, Begin LR, Wong N, Chappuis PO et al. (2005). Clin Cancer Res 11: 4003–4011.

  • Beger C, Pierce LN, Kruger M, Marcusson EG, Robbins JM, Welcsh P et al. (2001). Proc Natl Acad Sci USA 98: 130–135.

  • Brenton JD, Carey LA, Ahmed AA, Caldas C . (2005). J Clin Oncol 23: 7350–7360.

  • Buerger H, Mommers EC, Littmann R, Simon R, Diallo R, Poremba C et al. (2001). J Pathol 194: 165–170.

  • Buerger H, Otterbach F, Simon R, Poremba C, Diallo R, Decker T et al. (1999a). J Pathol 187: 396–402.

  • Buerger H, Otterbach F, Simon R, Schafer KL, Poremba C, Diallo R et al. (1999b). J Pathol 189: 521–526.

  • Catteau A, Morris JR . (2002). Semin Cancer Biol 12: 359–371.

  • Charafe-Jauffret E, Ginestier C, Monville F, Finetti P, Adelaide J, Cervera N et al. (2006). Oncogene 25: 2273–2284.

  • Chenevix-Trench G, Healey S, Lakhani S, Waring P, Cummings M, Brinkworth R et al. (2006). Cancer Res 66: 2019–2027.

  • Crook T, Brooks LA, Crossland S, Osin P, Barker KT, Waller J et al. (1998). Oncogene 17: 1681–1689.

  • Dairkee SH, Mayall BH, Smith HS, Hackett AJ . (1987). Lancet 1: 514.

  • Eerola H, Heikkila P, Tamminen A, Aittomaki K, Blomqvist C, Nevanlinna H . (2005a). Breast Cancer Res 7: R93–R100.

  • Eerola H, Heikkila P, Tamminen A, Aittomaki K, Blomqvist C, Nevanlinna H . (2005b). Breast Cancer Res 7: R465–R469.

  • Fan S, Wang J, Yuan R, Ma Y, Meng Q, Erdos MR et al. (1999). Science 284: 1354–1356.

  • Foulkes WD . (2004). J Med Genet 41: 1–5.

  • Foulkes WD, Brunet JS, Stefansson IM, Straume O, Chappuis PO, Begin LR et al. (2004a). Cancer Res 64: 830–835.

  • Foulkes WD, Metcalfe K, Sun P, Hanna WM, Lynch HT, Ghadirian P et al. (2004b). Clin Cancer Res 10: 2029–2034.

  • Foulkes WD, Stefansson IM, Chappuis PO, Begin LR, Goffin JR, Wong N et al. (2003). J Natl Cancer Inst 95: 1482–1485.

  • Fulford LG, Easton DF, Reis-Filho JS, Sofronis A, Gillet CE, Lakhani SR et al. (2006). Histopathology 49: 22–34.

  • Furuta S, Jiang X, Gu B, Cheng E, Chen PL, Lee WH . (2005). Proc Natl Acad Sci USA 102: 9176–9181.

  • Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, et al. (2002). Cell 111: 393–405.

  • Gould VE, Koukoulis GK, Jansson DS, Nagle RB, Franke WW, Moll R . (1990). Am J Pathol 137: 1143–1155.

  • Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH . (1996). Nat Genet 12: 191–194.

  • Gudmundsdottir K, Ashworth A . (2006). Oncogene 25: 5864–5874.

  • Gusterson BA, Ross DT, Heath VJ, Stein T . (2005). Breast Cancer Res 7: 143–148.

  • Hamperl H . (1970). Curr Top Pathol 53: 161–220.

  • Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C et al. (1999). Cell 97: 575–586.

  • Hedenfalk I, Duggan D, Chen Y, Radmacher M, Bittner M, Simon R et al. (2001). N Engl J Med 344: 539–548.

  • Hnasko R, Lisanti MP . (2003). Mol Interv 3: 445–464.

  • Honrado E, Benitez J, Palacios J . (2005a). Mod Pathol 18: 1305–1320.

  • Honrado E, Benitez J, Palacios J . (2006). Crit Rev Oncol Hematol 59: 27–39.

  • Honrado E, Osorio A, Palacios J, Benitez J . (2006). Oncogene 25: 5837–5845.

  • Honrado E, Osorio A, Palacios J, Milne RL, Sanchez L, Diez O et al. (2005b). J Clin Oncol 23: 7503–7511.

  • Hu Z, Fan C, Oh DS, Marron JS, He X, Qaqish BF et al. (2006). BMC Genomics 7: 96.

  • Hurlstone AF, Reid G, Reeves JR, Fraser J, Strathdee G, Rahilly M et al. (1999). Oncogene 18: 1881–1890.

  • Hwang ES, DeVries S, Chew KL, Moore II DH, Kerlikowske K, Thor A et al. (2004). Clin Cancer Res 10: 5160–5167.

  • Jacquemier J, Padovani L, Rabayrol L, Lakhani SR, Penault-Llorca F, Denoux Y et al. (2005). J Pathol 207: 260–268.

  • Jones C, Ford E, Gillett C, Ryder K, Merrett S, Reis-Filho JS et al. (2004a). Clin Cancer Res 10: 5988–5997.

  • Jones C, Mackay A, Grigoriadis A, Cossu A, Reis-Filho JS, Fulford L et al. (2004b). Cancer Res 64: 3037–3045.

  • Jones C, Nonni AV, Fulford L, Merrett S, Chaggar R, Eusebi V et al. (2001). Br J Cancer 85: 422–427.

  • Jones LP, Li M, Halama ED, Ma Y, Lubet R, Grubbs CJ et al. (2005). Oncogene 24: 3554–3562.

  • Jonsson G, Naylor TL, Vallon-Christersson J, Staaf J, Huang J, Ward MR et al. (2005). Cancer Res 65: 7612–7621.

  • Korsching E, Packeisen J, Agelopoulos K, Eisenacher M, Voss R, Isola J et al. (2002). Lab Invest 82: 1525–1533.

  • Laakso M, Loman N, Borg A, Isola J . (2005). Mod Pathol 18: 1321–1328.

  • Lacroix M, Toillon RA, Leclercq G . (2004). Endocr Relat Cancer 11: 497–522.

  • Lakhani SR, Jacquemier J, Sloane JP, Gusterson BA, Anderson TJ, van de Vijver MJ et al. (1998). J Natl Cancer Inst 90: 1138–1145.

  • Lakhani SR, O’Hare MJ . (2001). Breast Cancer Res 3: 1–4.

  • Lakhani SR, O’Hare MJ, Ashworth A . (2001). Nat Med 7: 408–410.

  • Lakhani SR, Reis-Filho JS, Fulford L, Penault-Llorca F, van der Vijver M, Parry S et al. (2005). Clin Cancer Res 11: 5175–5180.

  • Lakhani SR, Van De Vijver MJ, Jacquemier J, Anderson TJ, Osin PP, McGuffog L et al. (2002). J Clin Oncol 20: 2310–2318.

  • Livasy CA, Karaca G, Nanda R, Tretiakova MS, Olopade OI, Moore DT et al. (2006). Mod Pathol 19: 264–271.

  • Lou Z, Minter-Dykhouse K, Chen J . (2005). Nat Struct Mol Biol 12: 589–593.

  • Malzahn K, Mitze M, Thoenes M, Moll R . (1998). Virchows Arch 433: 119–129.

  • Marcus JN, Watson P, Page DL, Narod SA, Lenoir GM, Tonin P et al. (1996). Cancer 77: 697–709.

  • Matos I, Dufloth R, Alvarenga M, Zeferino LC, Schmitt F . (2005). Virchows Arch 447: 688–694.

  • Matros E, Wang ZC, Lodeiro G, Miron A, Iglehart JD, Richardson AL . (2005). Breast Cancer Res Treat 91: 179–186.

  • Moyano JV, Evans JR, Chen F, Lu M, Werner ME, Yehiely F et al. (2006). J Clin Invest 116: 261–270.

  • Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z et al. (2004). Clin Cancer Res 10: 5367–5374.

  • Osin P, Lu YJ, Stone J, Crook T, Houlston RS, Gasco M et al. (2003). Int J Surg Pathol 11: 153–158.

  • Page MJ, Amess B, Townsend RR, Parekh R, Herath A, Brusten L et al. (1999). Proc Natl Acad Sci USA 96: 12589–12594.

  • Palacios J, Honrado E, Osorio A, Cazorla A, Sarrio D, Barroso A et al. (2005). Breast Cancer Res Treat 90: 5–14.

  • Perez-Valles A, Martorell-Cebollada M, Nogueira-Vazquez E, Garcia-Garcia JA, Fuster-Diana E . (2001). J Clin Pathol 54: 476–480.

  • Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA et al. (2000). Nature 406: 747–752.

  • Pinilla SM, Honrado E, Hardisson D, Benitez J, Palacios J . (2006). Breast Cancer Res Treat (E-pub ahead of print: doi:10.1007/s10549-006-9184-1).

  • Polychronis A, Sinnett HD, Hadjiminas D, Singhal H, Mansi JL, Shivapatham D et al. (2005). Lancet Oncol 6: 383–391.

  • Quenneville LA, Phillips KA, Ozcelik H, Parkes RK, Knight JA, Goodwin PJ et al. (2002). Cancer 95: 2068–2075.

  • Raymond WA, Leong AS . (1989). J Pathol 157: 299–306.

  • Reis-Filho J, Pinheiro C, Lambros M, Milanezi F, Carvalho S, Savage K et al. (2006a). J Pathol 209: 445–453.

  • Reis-Filho JS, Milanezi F, Carvalho S, Simpson PT, Steele D, Savage K, et al. (2005a). Breast Cancer Res 7: R1028–R1035.

  • Reis-Filho JS, Milanezi F, Steele D, Savage K, Simpson PT, Nesland JM et al. (2006b). Histopathology 49: 10–21.

  • Reis-Filho JS, Savage K, Lambros MB, James M, Steele D, Jones RL et al. (2006c). Mod Pathol 19: 999–1009.

  • Reis-Filho JS, Simpson PT, Gale T, Lakhani SR . (2005b). Pathol Res Pract 201: 713–725.

  • Reis-Filho JS, Steele D, Di Palma S, Jones RL, Savage K, James M et al. (2006d). Mod Pathol 19: 307–319.

  • Reis-Filho JS, Westbury C, Pierga JY . (2006e). J Clin Pathol 59: 225–231.

  • Ribeiro-Silva A, Ramalho LN, Garcia SB, Brandao DF, Chahud F, Zucoloto S . (2005). Histopathology 47: 458–466.

  • Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A et al. (2006). Cancer Cell 9: 121–132.

  • Rodriguez-Pinilla SM, Sarrio D, Honrado E, Hardisson D, Calero F, Benitez J et al. (2006). Clin Cancer Res 12: 1533–1539.

  • Rouzier R, Perou CM, Symmans WF, Ibrahim N, Cristofanilli M, Anderson K et al. (2005). Clin Cancer Res 11: 5678–5685.

  • Roylance R, Gorman P, Harris W, Liebmann R, Barnes D, Hanby A et al. (1999). Cancer Res 59: 1433–1436.

  • Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML et al. (2006). Nature 439: 84–88.

  • Simpson PT, Gale T, Reis-Filho JS, Jones C, Parry S, Steele D et al. (2004). J Pathol 202: 274–285.

  • Simpson PT, Reis-Filho JS, Gale T, Lakhani SR . (2005). J Pathol 205: 248–254.

  • Sleeman KE, Kendrick H, Ashworth A, Isacke CM, Smalley MJ . (2006). Breast Cancer Res 8: R7.

  • Smalley M, Ashworth A . (2003). Nat Rev Cancer 3: 832–844.

  • Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H et al. (2001). Proc Natl Acad Sci USA 98: 10869–10874.

  • Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A et al. (2003). Proc Natl Acad Sci USA 100: 8418–8423.

  • Sotiriou C, Neo SY, McShane LM, Korn EL, Long PM, Jazaeri A et al. (2003). Proc Natl Acad Sci USA 100: 10393–10398.

  • Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D et al. (2006). Nature 439: 993–997.

  • Tirkkonen M, Kainu T, Loman N, Johannsson OT, Olsson H, Barkardottir RB et al. (1999). Genes Chromosomes Cancer 24: 56–61.

  • Tsuda H, Takarabe T, Hasegawa F, Fukutomi T, Hirohashi S . (2000). Am J Surg Pathol 24: 197–202.

  • Tsuda H, Takarabe T, Hasegawa T, Murata T, Hirohashi S . (1999). Hum Pathol 30: 1134–1139.

  • Turner N, Tutt A, Ashworth A . (2004). Nat Rev Cancer 4: 814–819.

  • van Beers EH, van Welsem T, Wessels LF, Li Y, Oldenburg RA, Devilee P et al. (2005). Cancer Res 65: 822–827.

  • van de Rijn M, Perou CM, Tibshirani R, Haas P, Kallioniemi O, Kononen J et al. (2002). Am J Pathol 161: 1991–1996.

  • van der Groep P, Bouter A, van der Zanden R, Menko FH, Buerger H, Verheijen RH et al. (2004). J Natl Cancer Inst 96: 712–713; author reply 714.

  • Vaziri SA, Krumroy LM, Elson P, Budd GT, Darlington G, Myles J et al. (2001a). Clin Cancer Res 7: 1937–1945.

  • Vaziri SA, Tubbs RR, Darlington G, Casey G . (2001b). Mol Pathol 54: 259–263.

  • Vos CB, ter Haar NT, Rosenberg C, Peterse JL, Cleton-Jansen AM, Cornelisse CJ et al. (1999). Br J Cancer 81: 1410–1418.

  • Waldman FM, DeVries S, Chew KL, Moore II DH, Kerlikowske K, Ljung BM . (2000). J Natl Cancer Inst 92: 313–320.

  • Wang ZC, Lin M, Wei LJ, Li C, Miron A, Lodeiro G et al. (2004). Cancer Res 64: 64–71.

  • Wessels LF, van Welsem T, Hart AA, van’t Veer LJ, Reinders MJ, Nederlof PM . (2002). Cancer Res 62: 7110–7117.

  • Williams TM, Lisanti MP . (2005). Am J Physiol Cell Physiol 288: C494–C506.

  • Zheng L, Annab LA, Afshari CA, Lee WH, Boyer TG . (2001). Proc Natl Acad Sci USA 98: 9587–9592.

Download references

Acknowledgements

We thank Alan Ashworth for helpful suggestions and critical reading of this manuscript.

Author information

Authors and Affiliations

  1. The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Fulham Road, London, UK

    N C Turner & J S Reis-Filho

Authors
  1. N C Turner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J S Reis-Filho
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to N C Turner or J S Reis-Filho.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Turner, N., Reis-Filho, J. Basal-like breast cancer and the BRCA1 phenotype. Oncogene 25, 5846–5853 (2006). https://doi.org/10.1038/sj.onc.1209876

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1209876

Keywords

Search

Advanced search

Quick links