Regular ArticlesSurvival after pancreaticoduodenectomy for periampullary adenocarcinoma: an update☆
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Cited by (71)
Advanced small bowel adenocarcinoma: Molecular characteristics and therapeutic perspectives
2016, Clinics and Research in Hepatology and GastroenterologyCitation Excerpt :The intestinal subtype was defined as having positive staining for CK20 or CDX2 or MUC2 and negative staining for MUC1, or positive staining for CK20, CDX2, and MUC2, irrespective of the MUC1 status; whereas the pancreatobiliary subtype was defined as having positive staining for MUC1 and negative staining for CDX2 and MUC2, whatever the CK20 results [31]. For patients with ampullary adenocarcinoma who undergo surgical resection, survival is similar to that observed in patients with resected duodenal adenocarcinoma, rather than in those with resected pancreatico-biliary carcinomas [32,33]. Gemcitabine or 5-fluorouracil adjuvant-based chemotherapy seems to be associated with a significant survival benefit in patients with periampullary adenocarcinoma [34].
Pancreatoduodenectomy associated complications influence cancer recurrence and time interval to death
2014, European Journal of Surgical OncologyCitation Excerpt :Our finding that postoperative complications are independently associated with death due to recurrence in pancreatic cancer might therefore better appreciated as earlier death due to recurrence. For pancreatic and periampullary adenocarcinoma several operation characteristics and pathological determinants have been demonstrated to influence long-term survival.21,27,28 Our study reconfirms the prognostic value of variables as resection margin status, lymph node metastasis or lymph node ratio, and tumour differentiation grade.
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Correspondence to: D. J. Gouma, MD, Academic Medical Center, Department of Surgery, Meibergdreef 9, PO Box 22660, 1100 DD Amsterdam, The Netherlands. Fax: +3120 691 48 58;E-mail: [email protected]