Aberrant expression of gland-type gastric mucin in the surface epithelium of Helicobacter pylori-infected patients
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A Complex Connection Between the Diversity of Human Gastric Mucin O-Glycans, Helicobacter pylori Binding, Helicobacter Infection and Fucosylation
2022, Molecular and Cellular ProteomicsMucins: Structural diversity, biosynthesis, its role in pathogenesis and as possible therapeutic targets
2018, Critical Reviews in Oncology/HematologyHistochemical study of the effects on abomasal mucins of Haemonchus contortus or Teladorsagia circumcincta infection in lambs
2016, Veterinary ParasitologyCitation Excerpt :Different epithelial tissues express genes for large secreted gel-forming mucins and smaller membrane-bound mucins. In the stomach, the secreted mucins are Muc5AC and Muc6 (Ho et al., 1995; Byrd et al., 1997), in contrast to Muc2 in the intestine and also Muc6 in the duodenum (de Bolos et al., 2001). The lower M.W. membrane-bound mucins are mainly Muc1 in the stomach and Muc2 and 3 in the intestine (Andrianifahanana et al., 2006).
The changes in MUC5AC expression in gastric cancer before and after Helicobacter pylori eradication
2014, Clinics and Research in Hepatology and GastroenterologyCitation Excerpt :The MUC5AC expressional changes in Hp positive human gastric mucosa has also been reported in some studies [1,4–7]. By reducing MUC5AC-producing cells and MUC5AC mucin, Hp might potentially cause significant alterations in the structure of gastric mucins [4] and the carbohydrate structure of MUC5AC mucin [5,8]. The expression of MUC5AC has been reported to be decreased or lost in certain neoplastic lesions and might abnormally appear in atypical hyperplasia of gastric mucous epithelium and early gastric cancer, especially advanced gastric cancer [9–15].
Quantitative MUC5AC and MUC6 mucin estimations in gastric mucus by a least-squares minimization method
2013, Analytical BiochemistryCitation Excerpt :Differences at the P < 0.05 level were considered to be statistically significant. In the human stomach, the protective mucus layer normally includes two mucins encoded by the MUC5AC and MUC6 genes [2,3], the proportions of which are reported to be altered in patients with H. pylori-associated peptic ulcer disease [6]. This prompted us to consider how to quantify these mucins in mucus from the gastric antrum, the site of H. pylori colonization.