Contribution of molecular genetic data to the classification of sarcomas
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Soft tissue sarcomas-New approaches to diagnosis and classification
2013, Current Problems in CancerRound Cell Tumors
2013, Practical Soft Tissue Pathology: A Diagnostic Approach A Volume in the Pattern Recognition SeriesA retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas
2012, European Journal of CancerCitation Excerpt :Chromosomal translocations are the most frequent molecular alterations in sarcomas, and occur in around 20% of cases.1ā4 Sarcoma translocations and the associated chimeric oncoproteins that they generate provide attractive targets for therapeutic intervention given that these fusion proteins are critical for disease pathogenesis and tumour cell survival, and no alternative pathways exist to avoid their blockade.5ā8 Trabectedin is a marine-derived antineoplastic agent, initially isolated from the tunicate Ecteinascidia turbinata and currently produced synthetically, which has shown antitumour activity in advanced soft tissue sarcoma (STS),9ā11 as well as in other malignancies such as relapsed ovarian cancer,12ā16 metastatic hormone-refractory prostate cancer,17 and advanced breast cancer.18,19
SYT-SSX1 (Synovial Sarcoma Translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein
2011, Journal of Biological Chemistry