Original contributionMolecular evidence that the stromal andepithelial cells in pleomorphic adenomas of salivary gland arise from the same origin: clonal analysis using Human Androgen Receptor Gene (HUMARA) Assay*
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Cited by (45)
Pleomorphic adenoma: detection of PLAG1 rearrangement–positive tumor components using whole-slide fluorescence in situ hybridization
2022, Human PathologyCitation Excerpt :The degrees of X-chromosome inactivation may differ considerably among the cell components examined. In addition, the degrees of inactivation may be significantly different depending on the age of the individual even in terms of the same cell components [7,17]. To accurately evaluate the clonality of a cell component of a tumor using the HUMARA clonality assay, an appropriate normal control should be used (for example, normal vs. tumor myoepithelial cells).
Head and Neck
2021, Gattuso’s Differential Diagnosis in Surgical PathologyBenign Tumors
2021, Surgery of the Salivary GlandsSalivary Glands
2020, Gnepp's Diagnostic Surgical Pathology of the Head and Neck, Third EditionMonoclonal origin of primary unilateral multifocal pleomorphic adenoma of the parotid gland
2013, Human PathologyCitation Excerpt :Genomic DNA was isolated by standard methods. Because the stromal and epithelial cells in a pleomorphic adenoma are clonally related, total DNA of the individual nine nodules was isolated, instead of separate microdissection of the stromal and epithelial cells [2,3,5]. Clonal relation between these nine nodules was assessed by a clonality assay based on random X-chromosome inactivation in females and amplification of the human androgen receptor (HUMARA) gene on the X-chromosome as described previously [2,3,6].
Salivary Gland Diseases
2011, Oral Pathology: Clinical Pathologic Correlations, Sixth Edition
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Supported by a grant from Harvey E. Nussbaum, MD, Research Institute of Saint Barnabas Medical Center.