Original ContributionsPathologic features of Hashimoto's-associated papillary thyroid carcinomas
Section snippets
Materials and methods
All the cases of concomitant HT and thyroid carcinomas, over the last 16 years, were retrieved from the files of the Thomas Jefferson Pathology Laboratory. Two of the authors (M.D.P., J.P.P.) reviewed all the available slides of each case to confirm the diagnosis of HT, evaluate its extension, and characterize each carcinoma. The age and sex of all the patients and the size of the tumors were recorded. Only cases that showed the classic pathologic features of HT, consisting of atrophic and
Results
A summary of the clinicopathologic features of patients with HT and carcinomas is presented in Table 1.Empty Cell Empty Cell Empty Cell HT Tumor Type Case No. Age/Sex Tumor Size (cm) Focal Diffuse Papillary Follicular/Hürthle Cell 1 22/M 3 X X 2 29/F 1 X X 3 27/F 1 X X 4 28/F 1.3 X X 5 24/F 2 X X 6 37/F 0.3 X X 7 34/F 0.3 X X 8 31/F 0.5 X X 9 40/F 3 X X 10 47/F 0.3 X X 11 55/F 1.8 X X 12 59/F 1.8 X X 13 51/F 0.3 X X 14 53/F 1 X X 15 53/F 0.7 X X 16 56/F 0.2 X X 17 65/M 2 X X 18 67/M 1.8 X X 19 60/M 0.5 X X 20 81/F 0.3 X X 21 78/F 0.7 X X 22 82/F 2 X X 23 60/F 0.7 X X 24 27/F 1.2 X X* 25 23/F 0.4
Discussion
In the current study the pathologic features of Hashimoto's-associated thyroid carcinomas and the possible significance of solid nodules present in these glands have been described. We did not obtain serologic information from our patients and followed the guidelines to classify chronic thyroiditis by Mizukami et al.9 For some investigators, focal chronic thyroiditis may be an early step in the development of HT; however, these patients may not have serologic evidence of auto-antibodies and may
Acknowledgements
The authors thank Dr Federico Monzon for his assistance with microphotography.
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