Case StudiesAdult-type hepatocellular carcinoma in the center of a fibrolamellar hepatocellular carcinoma*
Section snippets
Clinical data
This 27-year-old female patient was known to suffer from bronchial asthma for many years. Three months before the present admission to hospital, she started to complain of colic-like pain attacks in the epigastrium. These attacks, which then recurred almost every 2 weeks, lasted for about 5 minutes and were followed by vomiting, subfebrile temperatures, yellow feces, and intermittent diarrhea. Vasoactive intestinal peptide (VIP) or other gastrointestinal hormones were not measured. After these
Discussion
In this young female patient without hepatic cirrhosis, adult-type HCC developed in the center of a large FL-HCC as a circumscribed and not admixed lesion. In previous reports on FL-HCC components in liver carcinomas with an otherwise different histology, such components have been described as either admixed tumor parts with an unclear separation between HCC and FL-HCC morphologies,7, 8 or as FL-HCC representing a distinct differentiation pathway within an HCC,9 thus leaving unanswered the
Acknowledgements
The authors gratefully acknowledge secretarial help of Erna Kramel and the excellent work of the technicians.
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Address and reprint correspondence requests to: Arthur Zimmermann, MD Professor of Pathology, Institute of Pathology, University of Berne, Murtenstrasse 31, CH-3010 Berne, Switzerland.