Original ArticlesTrends in the identification and clinical features of celiac disease in a North American community, 1950–2001☆,☆☆
Section snippets
Study setting
Olmsted County, Minnesota, is a medically welldefined population in the upper Midwest. The population is largely white of Northern European extraction.13 Until recently, the population was almost entirely composed of whites of European extraction. In the last decade, there has been a recent influx of first Southeast Asian and then African ethnic groups so that the nonwhite group is about 10%. Population-based research is feasible in Olmsted County because medical care is virtually
Results
Eighty-two Olmsted County residents were diagnosed with biopsy-proven celiac disease between 1950 and 2001. There were substantially more females than males (58 vs. 24; P < 0.005). All patients were white of European extraction. There was a marked adult predominance (median age at diagnosis, 46 years; range, 1–84 years) (Figure 1). Less than 15% (12 of 82) of the patients were 18 years of age
Discussion
The incidence of celiac disease has been increasing in most European countries where it has been measured.12, 21, 22, 23 Consistent with these results, we have identified a dramatic increase, predominantly in the last decade, in this study from the upper Midwest of the United States. Our recent incidence rates are much greater than those reported previously.4 However, the recent incidence rates are equivalent to those for Crohn's disease and ulcerative colitis in the same population24, 25 and
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Address requests for reprints to: Joseph A. Murray, M.D., Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street, SW, Rochester, Minnesota 55905. e-mail: [email protected]; fax: (507) 284-0538.
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Supported in part by research grants DK 57982 (to J.A.M.) and AR 30582 (to L.J.M.) from the National Institutes of Health, US Public Health Service.