Abstract
The aim of this study was to explore the relationship between p53 and cyclin A immunostaining in squamous carcinomas of the oesophagus. It has been shown that both these proteins are over-expressed in poorly differentiated endometrial carcinomas. Fifty oesophagectomy specimens were analysed for p53 and cyclin A immunoexpression. This was correlated with patient age and gender and tumor stage and grade. Forty-two percent of cases were p53 positive, while 94% of the squamous cancers expressed cyclin A protein. Neither protein showed any statistically significant correlation with clinicopathological parameters. This study has demonstrated that only 42% of oesophageal squamous carcinomas from South Africa express p53 protein, while the vast majority (94%) express cyclin A protein. Neither of these proteins showed any relationship to each other or any clinical feature or the tumor grade or stage.
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References
Stemmermann G, Heffelfinger SC, Noffsinger A, et al: The molecular biology of esophageal and gastric cancer and their precursors: oncogenes, tumor suppressor genes, and growth fac-tors. Hum Pathol 25:968–981, 1994.
Motokura T, Arnold A: Cyclins and oncogenesis. Biochima et Biphysica Acta 1155:63–78, 1993.
Shiozawa T, Xin L, Nikaido T, et al: Immunohistochemical detection of cyclin A with reference to p53 expression in endometrial endometrioid carcinomas. Int J Gynecol Pathol 16:348–353, 1997.
Hollstein MA, Metcalf RA, Welsh JA, et al: Frequent mutation of the p53 gene in human esophageal cancer. Proc Natl Acad Sci USA 87:9958–9961, 1990.
Meltzer SJ, Yin J, Huang Y, et al: Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction. Proc Natl Acad Sci USA 88:4976–4980, 1991.
Uchino S, Saito T, Inomata M, et al: Prognostic significance of the p53 mutation in esophageal cancer. Jpn J Clin Oncol 26:287–292, 1996.
Wang DY, Xiang YY, Tanaka M, et al: High prevalence of p53 protein expression in patients with esophageal cancer in Linxian, China and its relationship to progression and prognosis. Cancer 74:3089–3096, 1994.
Sarbia M, Porschen R, Borchard F, et al: p53 protein expression and prognosis in squamous cell carcinoma of the esophagus. Cancer 74:2218–2223, 1994.
Shimaya K, Shiozaki H, Inoue M, et al: Significance of p53 expression as a prognostic factor in oesophageal squamous cell carcinoma. Virchows Archiv Pathol Anat Histopathology 422:271–276, 1993.
Chetty R, Chetty S: Cyclin DI and retinoblastoma protein expression in oesophageal squamous carcinoma. J Clin Pathol: Mol Pathol 50:257–260, 1997.
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RC is funded by the Cancer Association of South Africa, University of Natal Research Fund and the Medical Research Council of South Africa.
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Chetty, R., Simelane, S. p53 and cyclin a protein expression in squamous carcinoma of the oesophagus. Pathol. Oncol. Res. 5, 193–196 (1999). https://doi.org/10.1053/paor.1999.0196
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DOI: https://doi.org/10.1053/paor.1999.0196