ReportsBasaloid/follicular hyperplasia overlying connective tissue/mesenchymal hamartomas simulating basal cell carcinomas☆,☆☆,★,★★
Section snippets
Material and methods
Three patients had lesions that had been present for decades (Table I).
Ant, Anterior; F, female; M, male; W, white.Patient No. Age (y)/Sex/Race Location Size (cm) Duration (y) 1 71/F/W Left lateral ant low leg 3 >40 2 80/F/W Right forehead 5 × 6 40-50 3 42/F/W Right ant chest 4 × 5 cm >30
Discussion
We are not aware of any previous reports of basaloid hyperplasia overlying connective tissue/mesenchymal hamartomas. We believe that these hamartomas are distinct from NS and dermatofibromas with areas of basaloid hyperplasia. NS has been associated with multiple ectodermal and mesodermal malformations including other cutaneous hamartomas.2 However, unlike most reports of NS, the lesions in this report were not noticed until later in life, and they did not become verrucous. Only case 1 showed a
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Cited by (17)
A diagnostic approach to basaloid neoplasms of the skin: squamous is red; basals are blue but alas! If only that were true
2024, Diagnostic HistopathologyTumors of the epidermis
2009, Weedon's Skin Pathology: Third EditionBasal cell (trichoblastic) carcinoma. Common expression pattern for epithelial cell adhesion molecule links basal cell carcinoma to early follicular embryogenesis, secondary hair germ, and outer root sheath of the vellus hair follicle: A clue to the adnexal nature of basal cell carcinoma?
2008, Journal of the American Academy of DermatologyCitation Excerpt :We believe that we can extend our conclusions to BCC in general, because so far all clinicopathologic variants of BCC (eg, morpheiform, nodular, infiltrative, cystic, adenoid, granular) have been shown to consistently express Ep-CAM, as highlighted on staining with Ber-EP4.10,14,24-27 Interestingly, areas of basaloid hyperplasia overlying connective tissue hamartomas28 and organoid nevi29 have also been shown to be positive for Ber-EP4. The equivalent structures overlying the dermal component of some dermatofibromas react in an analogous manner (personal observation, unpublished).
Basaloid skin tumours: Mimics of basal cell carcinoma
2007, Current Diagnostic PathologyFollicular induction and CK20+ Merkel cells overlying cutaneous focal mucinosis
2019, Journal of Cutaneous PathologyCutaneous adnexal neoplasms
2017, Cutaneous Adnexal Neoplasms
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The opinions or assertions herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy, the Department of the Army, or the Department of Defense.
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Reprints not available from authors.
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*Drs Skelton and Smith are now with Dermatopathology, Departments of Dermatology and Pathology, University of Alabama at Birmingham.
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**Dr Corbett is now practicing in Wilson, North Carolina.