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The Role of Ultrasound-Guided Fine-Needle Aspiration of Axillary Nodes in the Staging of Breast Cancer

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

As a complement to sentinel node dissection (SLND), we evaluated ultrasound-guided fine-needle aspiration (USFNA) of normal and abnormal axillary nodes in breast cancer patients. We hypothesized that USFNA would be accurate for primary breast tumors larger than 2 cm.

Methods

We retrospectively reviewed 68 patients who underwent 69 preoperative USFNAs from 2003 to 2005. The results of 65 preoperative USFNA were compared with the results of SLND or axillary node dissection (ALND) for concordance. Four USFNAs were excluded from analysis because of a complete response to neoadjuvant therapy. We evaluated whether primary tumor features (histology, size, grade, vascular invasion, estrogen/progesterone receptor status and Her-2-neu status) predicted concordance of USFNA results and the final lymph node pathology.

Results

Of 65 axillae analyzed, 39 (60%) were positive, four (6%) were non-diagnostic, and 22 (34%) were negative by USFNA. USFNA had 89% sensitivity, 100% specificity, and 100% positive predictive value (PPV) in patients with palpable or ultrasonographically suspicious nodes. USFNA sensitivity dropped significantly for nonpalpable, ultrasonographically normal nodes (54%), while specificity and PPV remained 100%. None of the primary tumor features predicted concordance of USFNA and SLND/ALND.

Conclusions

USFNA of axillary nodes has a high specificity and PPV in clinically or radiologically suspicious nodes. Sensitivity of USFNA is low for nodes of normal appearance, but positive USFNA may allow definitive management of the axilla without a SLND. Thus, USFNA of normal appearing nodes might be beneficial in cases where decisions regarding neoadjuvant chemotherapy would be affected by the results.

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Authors and Affiliations

  1. Department of Surgery, Johns Hopkins University, Baltimore, USA

    Ajay Jain MD, Mary Ellen Haisfield-Wolfe MSN, Julie Lange MD, Nita Ahuja MD, Theodore Tsangaris MD, Charles Balch MD & Lisa K. Jacobs MD

  2. Department of Radiology, Johns Hopkins University, Baltimore, USA

    Nagi Khouri MD

  3. Biostatistics, Johns Hopkins University, Baltimore, USA

    Zhe Zhang MS

Authors
  1. Ajay Jain MD
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  2. Mary Ellen Haisfield-Wolfe MSN
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  3. Julie Lange MD
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  4. Nita Ahuja MD
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  5. Nagi Khouri MD
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  6. Theodore Tsangaris MD
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  7. Zhe Zhang MS
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  8. Charles Balch MD
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  9. Lisa K. Jacobs MD
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Corresponding author

Correspondence to Lisa K. Jacobs MD.

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Jain, A., Haisfield-Wolfe, M.E., Lange, J. et al. The Role of Ultrasound-Guided Fine-Needle Aspiration of Axillary Nodes in the Staging of Breast Cancer. Ann Surg Oncol 15, 462–471 (2008). https://doi.org/10.1245/s10434-007-9623-1

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  • DOI: https://doi.org/10.1245/s10434-007-9623-1

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