Chest
Original ResearchInterstitial Lung DiseasePathologic and Radiologic Differences Between Idiopathic and Collagen Vascular Disease-Related Usual Interstitial Pneumonia
Section snippets
Study Populations
UIP was diagnosed in a total of 320 patients (IPF/UIP, 272 patients; CVD-UIP, 48 patients) by surgical lung biopsy at the Asan Medical Center in South Korea from August 1991 to December 2007. Idiopathic pulmonary fibrosis was diagnosed according to the American Thoracic Society/European Respiratory Society consensus classification,13 and individual CVDs were diagnosed in patients according to the criteria of the corresponding societies.14, 15, 16, 17, 18, 19, 20 All patients with IPF/UIP lacked
Comparison of Clinical Findings Between CVD-UIP and IPF/UIP Patients
The mean age of the study population was 56.6 years, and 56.0% were men. The median follow-up period for all patients was 33.4 months. The underlying types of CVD were rheumatoid arthritis (n = 19), systemic sclerosis (n = 13), Sjögren syndrome (n = 3), undifferentiated connective tissue disease (n = 2), polymyositis (n = 1), and mixed connective tissue disease (n = 1). The CVD-UIP group was younger, and it included more women and nonsmokers compared with the IPF/UIP group (Table 1). However,
Discussion
In this study, we found that CVD-UIP and IPF/UIP patients show different pathologic features, despite having the same basic UIP pattern; CVD-UIP patients had more germinal centers and total inflammation with plasma cells and fewer fibroblastic foci and smaller HC spaces histologically compared with IPF/UIP patients. Radiologically, CVD-UIP patients showed a lesser extent of emphysema, higher prevalence of nontypical UIP pattern without HC, and a tendency for less HC, at the same degree of lung
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