Chest
Selected ReportsBronchogenic Squamous Cell Carcinoma Complicating Localized Recurrent Respiratory Papillomatosis
Section snippets
CASE REPORT
A 48-year-old woman was originally diagnosed as having RRP at 2 years of age when she presented with hoarseness and dyspnea. She had six separate tracheostomies for laryngeal papilloma resection in childhood. Following these, about 18 endoscopic laryngeal papilloma resections were performed. Between 1988 and July 1991, five endoscopic laser resections were performed.
After the last procedure, she developed a persistent cough. In November 1991, she developed fever and purulent sputum. She denied
DISCUSSION
Bronchogenic squamous cell carcinoma is a rare complication of RRP in the absence of a history of irradiation or smoking. In previous cases, it arose as a complication of RRP that extended into the tracheobronchial tree before diagnosis of the malignancy. In some cases, the malignancy was an incidental finding at autopsy of patients with RRP dying of pneumonia or respiratory failure.5
The unique feature of this case was the development of a bronchogenic squamous cell carcinoma in a patient in
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2009, Seminars in OncologyCitation Excerpt :SCJs have been detected in bronchial spurs82 and may explain how laryngeal papillomatosis spreads to the trachea and bronchi.83 The recurrent respiratory papillomatosis may result from the development of laryngeal and tracheobronchial papillomas81 and the subsequent development of well-differentiated squamous cell carcinoma of the pulmonary airways.84 Previous findings indicated that the existence of HPV infection in the upper respiratory or aerodigestive tract possibly resulted in HPV transmission to pulmonary airways and the subsequent development of lung tumor.
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2008, International Journal of Pediatric OtorhinolaryngologyCitation Excerpt :Two publications reported testing for only one type [36,66], and three publications reported testing for only HPV 6 and HPV 11 (10 patients) [5,86,110]. Fourteen patients, however, had tests for multiples types, including types 16 and 18 [1,14,28,30,37,41,52,85,92,100,105]. The other publications did not differentiate between type 6 and 11 [40,71,77] or type 16 and 18 [3,59].