Abstract
Dominik Wodarz and colleagues describe a mathematical model for the in vivo dynamics of human T-cell leukaemia virus type 1 (HTLV-I) infection and the virus-specific cytotoxic T lymphocyte response. They show that a high rate of viral replication is consistent with the relative sequence invariance of HTLV-I and might be necessary to maintain a persistent infection.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antiviral Agents / therapeutic use
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HTLV-I Infections / drug therapy
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HTLV-I Infections / immunology
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HTLV-I Infections / virology
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Human T-lymphotropic virus 1 / immunology*
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Human T-lymphotropic virus 1 / physiology
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Humans
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Mathematics
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Models, Biological
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T-Lymphocytes, Cytotoxic / immunology*
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Virus Replication