Abstract
The origin of CD5+ B cells remains controversial. The differential response to ligation of CD5 resulting in apoptosis or proliferation provides insight into its roles in distinct human B cells. Here, Pierre Youinou, Christophe Jamin and Peter Lydyard review current knowledge of B-1 and B-2 cells, and propose that CD5 has different functions when expressed by different B-cell subpopulations.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, CD / metabolism
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Antigens, Differentiation, B-Lymphocyte / metabolism
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Apoptosis
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B-Lymphocyte Subsets / cytology
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B-Lymphocyte Subsets / immunology*
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CD5 Antigens / metabolism*
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Cell Division
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Humans
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Ligands
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Lymphocyte Activation
Substances
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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CD5 Antigens
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CD72 protein, human
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Ligands