Knowledge of the chemokine superfamily has undergone a dramatic expansion during the past decade. Currently, we are witnessing a transition from a phase of molecular discovery to a phase of disease associations and the establishment of functional (clinical) relevance. Recent data regarding the expression of chemokines and their receptors in pathologically relevant cells as well as observations using gene-targeting approaches have given us a better understanding of the complex mechanisms involved in leukocyte recruitment and inflammation as well as their potential role in the immunopathogenesis of human diseases.