Cause of familial and multiple gastrointestinal autonomic nerve tumors with hyperplasia of interstitial cells of Cajal is germline mutation of the c-kit gene

Am J Surg Pathol. 2000 Feb;24(2):326-7. doi: 10.1097/00000478-200002000-00045.
No abstract available

Publication types

  • Letter

MeSH terms

  • Antigens, CD34 / metabolism
  • Autonomic Nervous System Diseases / genetics*
  • Autonomic Nervous System Diseases / metabolism
  • Autonomic Nervous System Diseases / pathology
  • DNA, Neoplasm / analysis
  • Digestive System / innervation
  • Digestive System / pathology*
  • Female
  • Gastrointestinal Neoplasms / genetics*
  • Gastrointestinal Neoplasms / metabolism
  • Gastrointestinal Neoplasms / pathology
  • Germ-Line Mutation
  • Humans
  • Hyperplasia
  • Immunohistochemistry
  • Myenteric Plexus / metabolism
  • Myenteric Plexus / pathology
  • Peripheral Nervous System Neoplasms / genetics*
  • Peripheral Nervous System Neoplasms / metabolism
  • Peripheral Nervous System Neoplasms / pathology
  • Point Mutation
  • Polymerase Chain Reaction
  • Proto-Oncogene Proteins c-kit / genetics*
  • Proto-Oncogene Proteins c-kit / metabolism

Substances

  • Antigens, CD34
  • DNA, Neoplasm
  • Proto-Oncogene Proteins c-kit