Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

Nat Genet. 2000 Oct;26(2):146-7. doi: 10.1038/79859.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Axin Protein
  • Base Pair Mismatch / genetics*
  • Cell Line
  • Colorectal Neoplasms / genetics*
  • Cytoskeletal Proteins / biosynthesis
  • Cytoskeletal Proteins / genetics*
  • Cytoskeletal Proteins / physiology*
  • DNA Mutational Analysis
  • DNA Repair / genetics*
  • Genes, Reporter
  • Humans
  • Mutation*
  • Signal Transduction
  • TCF Transcription Factors
  • Trans-Activators*
  • Transcription Factor 7-Like 2 Protein
  • Transcription Factors / physiology*
  • Transfection
  • beta Catenin

Substances

  • AXIN2 protein, human
  • Axin Protein
  • CTNNB1 protein, human
  • Cytoskeletal Proteins
  • TCF Transcription Factors
  • TCF7L2 protein, human
  • Trans-Activators
  • Transcription Factor 7-Like 2 Protein
  • Transcription Factors
  • beta Catenin