Abstract
This study was undertaken to assess the in vitro activity of gemifloxacin, five other fluoroquinolone antimicrobial agents (ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin and ofloxacin) and other non-quinolone comparator agents (ampicillin, erythromycin, clindamycin, doxycycline, penicillin and trimethoprim/sulphamethoxazole) against Streptococcus pneumoniae collected in the United States. Susceptibility testing of 550 S. pneumoniae, 290 Haemophilus influenzae and 205 Moraxella catarrhalis showed that 38.2% of pneumococci were penicillin nonsusceptible, while 26.2 and 95.6% of H. influenzae and M. catarrhalis, respectively, produced beta-lactamase. Overall new fluoroquinolones were the most active agents. The in vitro activity (based on MIC90 in mg/l) of the six fluoroquinolones was gemifloxacin>moxifloxacin>gatifloxacin>levofloxacin>ciprofloxacin and ofloxacin.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / pharmacology*
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Child
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Child, Preschool
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Community-Acquired Infections / drug therapy
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Community-Acquired Infections / microbiology
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Drug Resistance, Microbial
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Fluoroquinolones*
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Gemifloxacin
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Haemophilus influenzae / drug effects*
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Haemophilus influenzae / enzymology
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Haemophilus influenzae / isolation & purification
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Humans
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Microbial Sensitivity Tests
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Moraxella catarrhalis / drug effects*
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Moraxella catarrhalis / isolation & purification
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Moraxella catarrhalis / metabolism
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Naphthyridines / pharmacology*
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Respiratory Tract Infections / drug therapy
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Respiratory Tract Infections / microbiology
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / isolation & purification
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United States
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Fluoroquinolones
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Naphthyridines
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beta-Lactamases
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Gemifloxacin