Hepatoprotection via the IL-6/Stat3 pathway

J Clin Invest. 2003 Oct;112(7):978-80. doi: 10.1172/JCI19974.

Abstract

Stat3 is a vital transcription factor that is activated downstream of the gp130 receptor, primarily via IL-6 signaling in adult liver. A new study demonstrates that Stat3 provides hepatoprotection against Fas-mediated apoptotic liver damage by two mechanisms: direct inactivation of caspases and reduction of reactive oxygen species.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis*
  • Cell Survival
  • Cytoprotection*
  • DNA-Binding Proteins / physiology*
  • Interleukin-6 / physiology*
  • Liver / pathology*
  • Liver Regeneration
  • Mice
  • Oxidation-Reduction
  • STAT3 Transcription Factor
  • Signal Transduction
  • Trans-Activators / physiology*
  • fas Receptor / physiology*

Substances

  • DNA-Binding Proteins
  • Interleukin-6
  • STAT3 Transcription Factor
  • Stat3 protein, mouse
  • Trans-Activators
  • fas Receptor