Clinicopathological features and prognostic factors of Japanese patients with "peripheral T-cell lymphoma, unspecified" diagnosed according to the WHO classification

Leuk Res. 2004 Dec;28(12):1287-92. doi: 10.1016/j.leukres.2004.04.016.

Abstract

Clinicopathological features of 36 patients, male: 58.3%; median: 68 years, with "peripheral T-cell lymphoma, unspecified" diagnosed by the WHO criteria were reviewed. Majority (69.4%) had stage IV disease with frequent involvements into bone marrow, spleen, liver, and skin. According to the IPI, 72.2% were categorized as high or high-intermediate risk group. CR and PR were achieved in 12 and 10 out of 31 patients treated by CHOP-based chemotherapy, respectively. One- and two-year overall survivals were 60.6 and 25.0%, respectively. Performance status, serum LDH, and B symptom were significant prognostic factors. Survival of CD4-/CD8+ cases, corresponding to cytotoxic T-cell lymphoma, was significantly worse than that of CD4+/CD8-.

MeSH terms

  • Adult
  • Aged
  • CD4-CD8 Ratio
  • Classification
  • Female
  • Humans
  • Immunohistochemistry
  • Japan
  • Lymphoma, T-Cell, Peripheral / classification*
  • Lymphoma, T-Cell, Peripheral / diagnosis*
  • Lymphoma, T-Cell, Peripheral / drug therapy
  • Male
  • Middle Aged
  • Prognosis
  • Remission Induction
  • Retrospective Studies
  • Risk Factors
  • Survival Rate
  • T-Lymphocytes, Cytotoxic
  • Treatment Outcome
  • World Health Organization