Mapping of the human GSPT1 gene, a human homolog of the yeast GST1 gene, to chromosomal band 16p13.1

Somat Cell Mol Genet. 1992 Mar;18(2):189-94. doi: 10.1007/BF01233164.

Abstract

The GSPT1 gene, a human homolog of the yeast GST1 gene (formerly named GST1-Hs), was mapped on human chromosome 16p13.1 by a combination of nonradioactive in situ hybridization and Giemsa staining. Southern blot hybridization with a panel of human-rodent somatic cells confirmed the location of the GSPT1 gene on chromosome 16 and also showed the existence of a homologous gene on the X chromosome. A breakpoint for nonrandom chromosome rearrangements has been found in the region of GSPT1 in patients with acute nonlymphocytic leukemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Southern
  • Chromosome Mapping
  • Chromosomes, Human, Pair 16*
  • Glutathione Transferase / genetics*
  • Humans
  • Hybrid Cells
  • Leukemia, Myeloid, Acute / genetics*
  • Nucleic Acid Hybridization
  • Sequence Homology, Nucleic Acid
  • X Chromosome

Substances

  • Glutathione Transferase