Abstract
The minichromosome maintenance (Mcm) and Cdc6 proteins are important regulators of eucaryotic DNA replication. In most normal tissues, a similar proportion of cells express Mcm-2 and Ki-67. The present study showed that in both normal and abnormal states, the proportion of megakaryocytes expressing Mcm-2 is roughly seven times as many as those that express Ki-67. This is likely to be related to the process of endomitosis and endoreduplication. We also demonstrated that a significantly lower proportion of megakaryocytes in myelodysplastic syndrome express Mcm-2. These findings provide new insights into megakaryocyte biology.
MeSH terms
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Bone Marrow / metabolism
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Cell Cycle Proteins / metabolism*
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Cell Nucleus / metabolism
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Cytoplasm / metabolism
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Erythroid Precursor Cells / metabolism
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Humans
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Integrin beta3 / metabolism
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Ki-67 Antigen / metabolism*
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Megakaryocytes / metabolism*
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Minichromosome Maintenance Complex Component 2
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Myelodysplastic Syndromes / metabolism*
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Myelodysplastic Syndromes / pathology
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Myeloproliferative Disorders / metabolism*
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Myeloproliferative Disorders / pathology
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Nuclear Proteins / metabolism*
Substances
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Cell Cycle Proteins
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ITGB3 protein, human
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Integrin beta3
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Ki-67 Antigen
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Nuclear Proteins
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MCM2 protein, human
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Minichromosome Maintenance Complex Component 2