Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor I

J Haylor; I Singh; A M el Nahas

doi:10.1038/ki.1991.42

Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor I

Kidney Int. 1991 Feb;39(2):333-5. doi: 10.1038/ki.1991.42.

Authors

J Haylor¹, I Singh, A M el Nahas

Affiliation

¹ Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, England, United Kingdom.

PMID: 2002647
DOI: 10.1038/ki.1991.42

Abstract

The effect of insulin-like growth factor I (IGF-I) on renal blood flow was measured in the anaesthetized rat using an electromagnetic flow probe. Renal vasodilation induced by IGF-I (50 micrograms/kg) was completely inhibited by NG-nitro-l-arginine methyl ester (50 mg/kg), an inhibitor of nitric oxide biosynthesis, but only partially reduced by indomethacin (10 mg/kg). The involvement of nitric oxide synthesis in the renal actions of IGF-I is proposed.

MeSH terms

Animals
Arginine / analogs & derivatives*
Arginine / pharmacology
Indomethacin / pharmacology
Insulin-Like Growth Factor I / antagonists & inhibitors*
Insulin-Like Growth Factor I / pharmacology
Kidney / blood supply*
Male
NG-Nitroarginine Methyl Ester
Nitric Oxide / antagonists & inhibitors*
Nitric Oxide / chemistry
Nitric Oxide / physiology*
Rats
Rats, Inbred Strains
Renal Circulation / drug effects
Vasodilation / drug effects*

Substances

Nitric Oxide
Insulin-Like Growth Factor I
Arginine
NG-Nitroarginine Methyl Ester
Indomethacin