Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma

Leukemia. 2010 Oct;24(10):1804-7. doi: 10.1038/leu.2010.168. Epub 2010 Aug 12.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols
  • Apoptosis / drug effects*
  • Benzhydryl Compounds / pharmacology
  • Benzoquinones / pharmacology
  • Blotting, Western
  • Cell Cycle
  • Cell Proliferation
  • Drug Synergism
  • HSP72 Heat-Shock Proteins / antagonists & inhibitors*
  • HSP72 Heat-Shock Proteins / genetics
  • HSP72 Heat-Shock Proteins / metabolism
  • HSP90 Heat-Shock Proteins / antagonists & inhibitors*
  • HSP90 Heat-Shock Proteins / metabolism
  • Humans
  • Lactams, Macrocyclic / pharmacology
  • Multiple Myeloma / drug therapy*
  • Multiple Myeloma / metabolism
  • Multiple Myeloma / pathology*
  • Pyrrolidinones / pharmacology
  • RNA, Messenger / genetics
  • RNA, Small Interfering / pharmacology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription Factor CHOP / genetics
  • Transcription Factor CHOP / metabolism
  • Tumor Cells, Cultured

Substances

  • Benzhydryl Compounds
  • Benzoquinones
  • DDIT3 protein, human
  • HSP72 Heat-Shock Proteins
  • HSP90 Heat-Shock Proteins
  • KNK 437
  • Lactams, Macrocyclic
  • Pyrrolidinones
  • RNA, Messenger
  • RNA, Small Interfering
  • Transcription Factor CHOP
  • tanespimycin