Abstract
Using the flow-cytofluorometric technique, 47 consecutive cases of pituitary tumours were analyzed regarding DNA ploidy and the percentage of cells in different phases of the cell cycle. About 20,000-30,000 cells from each tumour were analyzed. Tumours causing acromegaly showed a higher incidence of high percentages of S-phase cells (greater than or equal to 10%) than any other endocrinological type of pituitary tumour. 3 of 6 tumours with high percentages of S-phase cells showed clinically aggressive growth patterns.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acromegaly / etiology
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Adolescent
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Adrenocorticotropic Hormone / metabolism
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Adult
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Aged
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Aneuploidy
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Cell Cycle
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Cell Division*
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Child
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DNA, Neoplasm / genetics
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Diploidy
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Female
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Flow Cytometry
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Growth Hormone / metabolism
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Humans
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Male
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Middle Aged
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Pituitary Gland, Anterior / pathology*
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Pituitary Neoplasms / genetics
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Pituitary Neoplasms / metabolism
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Pituitary Neoplasms / pathology*
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Prolactin / metabolism
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Thyrotropin / metabolism
Substances
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DNA, Neoplasm
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Adrenocorticotropic Hormone
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Prolactin
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Thyrotropin
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Growth Hormone