The coexistence of Kaposi's sarcoma (KS) and Hodgkin's disease (HD) in the same lymph node is illustrated. The case concerns an 82-year-old Italian woman with a classic cutaneous KS who developed multiple lymphadenopathies. Involvement of a single node by KS and HD in the manner of a collision tumor was found unexpectedly. This very unusual finding might be regarded as more than coincidental because of the relatively frequent concurrence of diseases.