Homology and concerted evolution at the alpha 1 and alpha 2 loci of human alpha-globin

Nature. 1981 Mar 5;290(5801):26-9. doi: 10.1038/290026a0.

Abstract

The identical structure of two racially distinct alpha 1-globin alleles and the high degree of homology between the alpha 1- and alpha 2-globin loci indicate that mechanisms exist for suppression of allelic polymorphisms and for exchange of genetic information within the alpha-globin gene complex.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Asian People
  • Base Sequence
  • Cloning, Molecular
  • DNA / genetics
  • Escherichia coli / genetics
  • Globins / genetics*
  • Humans
  • Phylogeny*
  • Plasmids
  • Polymorphism, Genetic
  • White People

Substances

  • Globins
  • DNA

Associated data

  • GENBANK/J00079
  • GENBANK/J00153
  • GENBANK/J00154
  • GENBANK/J00155
  • GENBANK/J00156
  • GENBANK/K00418
  • GENBANK/X00168