Abstract
A simple rapid platelet aggregation test was used to evaluate cross-reactivity of four low molecular weight heparins and the heparinoid ORG 10172 in three patients with heparin-induced thrombocytopenia. The low molecular weight heparins cross-reacted in 11 out of 12 tests. The heparinoid ORG 10172 did not cross-react in any of the patients. One patient was treated with ORG 10172 and thrombocytopenia resolved.
MeSH terms
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Adult
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Aged
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Anticoagulants / pharmacology*
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Chondroitin Sulfates*
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Cross Reactions
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Dermatan Sulfate*
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Female
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Glycosaminoglycans / pharmacology*
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Heparin / adverse effects
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Heparin, Low-Molecular-Weight / pharmacology*
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Heparinoids / pharmacology
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Heparitin Sulfate*
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Humans
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Platelet Aggregation / drug effects*
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Thrombocytopenia / chemically induced*
Substances
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Anticoagulants
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Glycosaminoglycans
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Heparin, Low-Molecular-Weight
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Heparinoids
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Dermatan Sulfate
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Heparin
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Chondroitin Sulfates
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Heparitin Sulfate
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danaparoid