Abstract
A great deal is known about the immunology of cytotoxic T lymphocyte killing, but much less is known about the cell biology of this process. Recent work has begun to elucidate the mechanisms that control lytic-protein secretion, and reveals that some unusual features of these secretory processes might explain some of the important features of killing by cytotoxic T lymphocytes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Apoptosis
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Cell Communication / immunology
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Cytoplasmic Granules
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Cytotoxicity, Immunologic
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Endocytosis
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Epitopes
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Humans
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Models, Immunological
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Organelles / immunology
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Organelles / physiology
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Receptors, Antigen, T-Cell / immunology
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Receptors, Antigen, T-Cell / physiology
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Signal Transduction
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T-Lymphocytes, Cytotoxic / immunology*
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T-Lymphocytes, Cytotoxic / physiology
Substances
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Epitopes
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Receptors, Antigen, T-Cell