Abstract
A central question in T-cell immunity concerns the nature of intracellular signaling from the antigen receptor, the CD4/CD8 co-receptors and the CD28 antigen. Since the original discovery that T-cell receptors such as CD4 can interact with intracellular protein-tyrosine kinases such as p56lck, remarkable progress has been made in deciphering the signaling pathways that control T-cell growth and immune function. Here, Christopher Rudd and colleagues examine the role of protein-tyrosine kinases, SH2/SH3 domains and lipid kinases in the generation of signals from the TCR zeta/CD3 complex and the CD28 antigen.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, CD / immunology*
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Binding Sites
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CD28 Antigens / immunology
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CD3 Complex / immunology
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CD4 Antigens / immunology
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Humans
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Membrane Proteins / immunology*
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Molecular Sequence Data
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Phosphotransferases (Alcohol Group Acceptor) / metabolism
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Protein-Tyrosine Kinases / metabolism*
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Receptors, Antigen, T-Cell / immunology*
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Signal Transduction / immunology*
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T-Lymphocytes / enzymology
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T-Lymphocytes / immunology*
Substances
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Antigens, CD
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CD28 Antigens
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CD3 Complex
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CD4 Antigens
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Membrane Proteins
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Receptors, Antigen, T-Cell
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antigen T cell receptor, zeta chain
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Phosphotransferases (Alcohol Group Acceptor)
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Protein-Tyrosine Kinases