Left ventricular (LV) remodeling after LV myocardial infarction was described previously. Little is known regarding concomitant adaptation, if any, in right ventricular (RV) volumes after LV infarction. To examine this issue, cine-computed tomography was used to determine serial changes in absolute global LV and RV volumes in 27 patients without clinical heart failure during the first year after an initial Q-wave myocardial infarction (14 anterior and 13 inferior). The patient group with anterior wall LV infarction showed progressive increases in LV and RV volumes from hospital discharge to 1 year (end-diastolic volumes +25 and +13%, respectively; and end-systolic volumes +35 and +15%, respectively). In patients with inferior wall LV infarction, both LV end-diastolic and end-systolic volumes increased significantly during the study period (+13 and +15%, respectively). Despite a trend for RV end-diastolic volume to be increased at 1 year, neither end-diastolic nor end-systolic volume increased significantly after hospital discharge following inferior wall LV infarction. Absolute RV end-diastolic volume was not significantly different between the infarct groups at any time after infarction. In conclusion, global changes occur in both LV and RV volumes during the first year after an initial infarction regardless of infarct location. The magnitude of these changes was greater after anterior than inferior wall LV infarction.