Abstract
This was an open-label study comparing effects of a nonhormonal drug-free bioadhesive vaginal moisturizer to a local estrogen therapy in the treatment of vaginal dryness symptoms. There were 15 women evaluated in each treatment group during a 12-week period. Results indicated that the bioadhesive vaginal moisturizer was a safe and effective alternative to estrogen vaginal cream, with both therapies exhibiting statistically significant increases in vaginal moisture, vaginal fluid volume, and vaginal elasticity with a return of the premenopausal pH state.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Topical
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Estrogen Replacement Therapy / methods*
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Estrogens, Conjugated (USP) / administration & dosage
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Estrogens, Conjugated (USP) / pharmacology
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Estrogens, Conjugated (USP) / therapeutic use*
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Female
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Humans
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Hydrogen-Ion Concentration
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Lipids
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Menopause*
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Middle Aged
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Vagina / drug effects*
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Vagina / metabolism
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Vagina / pathology
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Vaginal Creams, Foams, and Jellies / pharmacology
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Vaginal Creams, Foams, and Jellies / therapeutic use*
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Vaginal Diseases / drug therapy*
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Vaginal Smears
Substances
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Estrogens, Conjugated (USP)
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Lipids
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Replens
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Vaginal Creams, Foams, and Jellies