Parvovirus B19-associated haemophagocytic syndrome with lymphadenopathy resembling histiocytic necrotizing lymphadenitis (Kikuchi's disease)

Y Yufu; M Matsumoto; T Miyamura; J Nishimura; H Nawata; K Ohshima

doi:10.1046/j.1365-2141.1997.d01-2099.x

Parvovirus B19-associated haemophagocytic syndrome with lymphadenopathy resembling histiocytic necrotizing lymphadenitis (Kikuchi's disease)

Br J Haematol. 1997 Mar;96(4):868-71. doi: 10.1046/j.1365-2141.1997.d01-2099.x.

Authors

Y Yufu¹, M Matsumoto, T Miyamura, J Nishimura, H Nawata, K Ohshima

Affiliation

¹ Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

PMID: 9074434
DOI: 10.1046/j.1365-2141.1997.d01-2099.x

Abstract

A 15-year-old girl developed a haemophagocytic syndrome caused by human parvovirus B19 (PVB19). The cervical lymph node histology, resembling that of histiocytic necrotizing lymphadenitis (HNL, Kikuchi's disease), included several transformed lymphocytes, numerous histocytes, and massive necrosis. We detected PVB19-positive cells in the lymph node by immunohistochemistry. Possible autoimmune mechanisms in HNL-like diseases triggered by PVB19 are discussed.

Publication types

Case Reports

MeSH terms

Adolescent
Female
Histiocytosis, Non-Langerhans-Cell / drug therapy
Histiocytosis, Non-Langerhans-Cell / virology*
Humans
Immunohistochemistry
Lymphadenitis / drug therapy
Lymphadenitis / virology*
Necrosis
Parvoviridae Infections / complications*
Parvoviridae Infections / drug therapy
Parvovirus B19, Human
Prednisolone / therapeutic use
Syndrome

Substances

Prednisolone