Abstract
The clinical records and autopsy material from 14 patients treated with cyclosporine who were not recipients of cardiac allografts were reviewed to further study the nature of endocardial lymphoid infiltrates (quilty lesions). Although there was well-documented exposure to cyclosporine, no endocardial lymphoid infiltrates were identified in these cases, providing evidence that the endocardial-based Quilty lesion is not the result of the direct effect of cyclosporine and may represent a localized form of heart rejection confined to the endocardium.
MeSH terms
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Adolescent
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Adult
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Aged
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Biopsy
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Cardiomyopathies / chemically induced*
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Cardiomyopathies / pathology
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Cyclosporine / adverse effects*
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Cyclosporine / therapeutic use
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Endocardium / drug effects
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Endocardium / pathology
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Female
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Graft Rejection / drug therapy*
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Graft Rejection / pathology
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Humans
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Immunosuppressive Agents / adverse effects*
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Immunosuppressive Agents / therapeutic use
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Kidney Transplantation / pathology
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Liver Transplantation / pathology
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Lung Transplantation / pathology
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Lymphocytosis / chemically induced*
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Lymphocytosis / pathology
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Male
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Middle Aged
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Pseudolymphoma / chemically induced*
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Pseudolymphoma / pathology
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Thalassemia / drug therapy
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Thalassemia / pathology
Substances
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Immunosuppressive Agents
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Cyclosporine