Abstract
Expression of CD44 (m.w. 80-95 kD) in 48 metastatic brain tumors was examined using monoclonal antibody on paraffin sections. The CD44 expression was found in 48% of studied tumors. The most constant expression of CD44 was observed in metastases from thyroid, skin and breast cancer. The brain metastases were characterized by quite heterogenous distribution of CD44 glycoprotein--the most pronounced expression was seen in individual neoplastic cells embedded in abundant stroma and in the vicinity of preserved neural tissue. Such a topographical distribution of CD44 supports its role in interactions of cancer cells with extracellular matrix components of the tumor stroma as well as of neural tissue.
MeSH terms
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Adenocarcinoma / genetics
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Adenocarcinoma / metabolism
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Adenocarcinoma / secondary*
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Adult
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Aged
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Antibodies, Monoclonal / immunology
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Brain Neoplasms / genetics
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Brain Neoplasms / metabolism
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Brain Neoplasms / secondary*
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Breast Neoplasms / pathology
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Cell Adhesion
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Colonic Neoplasms / pathology
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Female
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Gene Expression Regulation, Neoplastic*
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Glioblastoma / genetics
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Glioblastoma / metabolism
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Glioblastoma / secondary
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Humans
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Hyaluronan Receptors / biosynthesis*
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Hyaluronan Receptors / genetics
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Hyaluronan Receptors / immunology
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Male
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Melanoma / genetics
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Melanoma / metabolism
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Melanoma / secondary*
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Middle Aged
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
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Neoplasm Proteins / immunology
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Skin Neoplasms / pathology
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Thyroid Neoplasms / pathology
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Urinary Bladder Neoplasms / pathology
Substances
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Antibodies, Monoclonal
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Hyaluronan Receptors
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Neoplasm Proteins