Recent advances in the study of the regulation of cell death by apoptosis suggest that
changes in mitochondrial permeability frequently precede the development of morphological …

Although the alkylating agents were amongst the first non-hormonal compounds to be
shown to be active against malignant cells they still rank as some of the most valuable …

We conducted a genome-wide association study of 299,983 tagging SNPs for chronic
lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 …

Introduction: Obesity is treatment-resistant, and is linked with a number of serious, chronic
diseases. Adult obesity rates in the United States have tripled since the early 1960s. Recent …

To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a
genome-wide association study of 299,983 tagging SNPs, with validation in four additional …

Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have
shown that common genetic variation contributes to the heritable risk of CLL. To identify …

Mitochondrial DNA (mtDNA) defects cause debilitating metabolic disorders for which there is
no effective treatment. Patients suffering from these diseases often harbour both a wild‐type …

Inactivation of the tumor suppressor gene, CDKN2A, can occur by deletion, methylation, or
mutation. We assessed the principal mode of inactivation in childhood acute lymphoblastic …

Results A total of 56%, 27%, and 17% of referred patients were evaluated, were placed on
the waiting list, and received a transplant over the study period, respectively. Older age …

During the last 50 years, the health of the US population has improved substantially.
Mortality and morbidity rates are declining while life expectancy has increased. Although …