Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect …
JJM Van Dongen, AW Langerak, M Brüggemann… - Leukemia, 2003 - nature.com
In a European BIOMED-2 collaborative study, multiplex PCR assays have successfully been
developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) …
developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) …
Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease
JJM Van Dongen, EA Macintyre, JA Gabert… - Leukemia, 1999 - nature.com
Prospective studies on the detection of minimal residual disease (MRD) in acute leukemia
patients have shown that large-scale MRD studies are feasible and that clinically relevant …
patients have shown that large-scale MRD studies are feasible and that clinically relevant …
[HTML][HTML] EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations
AW Langerak, PJTA Groenen, M Brüggemann… - Leukemia, 2012 - nature.com
Abstract PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected
lymphoproliferations has largely been standardized and has consequently become …
lymphoproliferations has largely been standardized and has consequently become …
[HTML][HTML] Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions
V Goede, K Fischer, R Busch, A Engelke… - … England Journal of …, 2014 - Mass Medical Soc
Background The monoclonal anti-CD20 antibody rituximab, combined with
chemotherapeutic agents, has been shown to prolong overall survival in physically fit …
chemotherapeutic agents, has been shown to prolong overall survival in physically fit …
[HTML][HTML] Venetoclax and obinutuzumab in patients with CLL and coexisting conditions
K Fischer, O Al-Sawaf, J Bahlo, AM Fink… - … England Journal of …, 2019 - Mass Medical Soc
Background The BCL2 inhibitor venetoclax has shown activity in patients with chronic
lymphocytic leukemia (CLL), but its efficacy in combination with other agents in patients with …
lymphocytic leukemia (CLL), but its efficacy in combination with other agents in patients with …
[HTML][HTML] EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes
JJM Van Dongen, L Lhermitte, S Böttcher, J Almeida… - Leukemia, 2012 - nature.com
Most consensus leukemia & lymphoma antibody panels consist of lists of markers based on
expert opinions, but they have not been validated. Here we present the validated EuroFlow …
expert opinions, but they have not been validated. Here we present the validated EuroFlow …
New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling
WA Dik, K Pike-Overzet, F Weerkamp… - The Journal of …, 2005 - rupress.org
To gain more insight into initiation and regulation of T cell receptor (TCR) gene
rearrangement during human T cell development, we analyzed TCR gene rearrangements …
rearrangement during human T cell development, we analyzed TCR gene rearrangements …
Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies
A Agathangelidis, N Darzentas… - Blood, The Journal …, 2012 - ashpublications.org
Mounting evidence indicates that grouping of chronic lymphocytic leukemia (CLL) into
distinct subsets with stereotyped BCRs is functionally and prognostically relevant. However …
distinct subsets with stereotyped BCRs is functionally and prognostically relevant. However …
[PDF][PDF] Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia
I Homminga, R Pieters, AW Langerak, JJ de Rooi… - Cancer cell, 2011 - cell.com
To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we
combined expression profiling of 117 pediatric patient samples and detailed molecular …
combined expression profiling of 117 pediatric patient samples and detailed molecular …
The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL …
E Clappier, W Cuccuini, A Kalota… - Blood, The Journal …, 2007 - ashpublications.org
The C-Myb transcription factor is essential for hematopoiesis, including in the T-cell lineage.
The C-Myb locus is a common site of retroviral insertional mutagenesis, however no …
The C-Myb locus is a common site of retroviral insertional mutagenesis, however no …