RGS1 expression is associated with poor prognosis in multiple myeloma

J Roh, SJ Shin, AN Lee, DH Yoon, C Suh… - Journal of clinical …, 2017 - jcp.bmj.com
Aims Multiple myeloma (MM) is an invariably fatal disease with highly heterogeneous
outcome. Because of this heterogeneity of MM, risk stratification is crucial for therapeutic …

TBK1-targeted suppression of TRIF-dependent signaling pathway of toll-like receptor 3 by auranofin

SJ Park, AN Lee, HS Youn - Archives of pharmacal research, 2010 - Springer
Toll-like receptors (TLRs) play an important role in induction of innate immune responses.
The stimulation of TLRs by microbial components triggers two branches of downstream …

[HTML][HTML] Regulator of G protein signaling 1 suppresses CXCL12-mediated migration and AKT activation in RPMI 8226 human plasmacytoma cells and plasmablasts

HK Pak, M Gil, Y Lee, H Lee, AN Lee, J Roh, CS Park - PloS one, 2015 - journals.plos.org
Migration of plasma cells to the bone marrow is critical factor to humoral immunity and
controlled by chemokines. Regulator of G protein signaling 1 (RGS1) is a GTPase-activating …

[HTML][HTML] The immune checkpoint molecule V-set Ig domain-containing 4 is an independent prognostic factor for multiple myeloma

J Roh, Y Jeon, AN Lee, SM Lee, YM Kim, CO Sung… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Multiple myeloma (MM) remains as an incurable disease, despite recent substantial
improvements in treatment. Therefore, development of novel biomarkers for risk stratification …

[HTML][HTML] Engagement of CD99 reduces AP-1 activity by inducing BATF in the human multiple myeloma cell line RPMI8226

M Gil, HK Pak, SJ Park, AN Lee, YS Park, H Lee… - Immune …, 2015 - ncbi.nlm.nih.gov
CD99 signaling is crucial to a diverse range of biological functions including survival and
proliferation. CD99 engagement is reported to augment activator protein-1 (AP-1) activity …

[HTML][HTML] Risk stratification using multivariable fractional polynomials in diffuse large B-cell lymphoma

J Roh, J Jung, Y Lee, SW Kim, HK Pak, AN Lee… - Frontiers in …, 2020 - frontiersin.org
The risk stratification of diffuse large B-cell lymphoma (DLBCL) is crucial. The International
Prognostic Index, the most commonly used and the traditional risk stratification system, is …

Costunolide inhibits cyclooxygenase-2 expression induced by Toll-like receptor 3 or 4 agonist

SJ Park, SM Yun, AN Lee, SII Ahn, MY Lee… - Toxicology and …, 2009 - Springer
Toll-like receptors (TLRs) play an important role in the induction of innate immune
responses recognizing conserved microbial structural molecules. The microbial pathogens …

CD99 regulates CXCL12-induced chemotaxis of human plasma cells

M Gil, HK Pak, AN Lee, SJ Park, Y Lee, J Roh, H Lee… - Immunology …, 2015 - Elsevier
Migration of plasma cells (PCs) is crucial for the control of PC survival and antibody
production and is controlled by chemokines, most importantly by CXCL12. This study …

[HTML][HTML] Quantitative analysis of tumor-specific BCL2 expression in DLBCL: refinement of prognostic relevance of BCL2

J Roh, H Cho, DH Yoon, JY Hong, AN Lee, HS Eom… - Scientific Reports, 2020 - nature.com
BCL2 overexpression has been reported to be associated with poor prognosis in patients
with diffuse large B-cell lymphoma (DLBCL). However, currently there is no consensus on …

Oak wood vinegar suppresses the expression of cyclooxygenase-2 induced by TLR4 agonist

S Park, A Lee, S Ahn - J. Exp. Biomed. Sci., 2009 - bslonline.org
Toll-like receptors (TLRs) recognize molecular structures derived from microbes including
bacteria, viruses, yeast, and fungi. TLRs have emerged as a major signaling component of …