A main limitation of therapies that selectively target kinase signalling pathways is the
emergence of secondary drug resistance. Cetuximab, a monoclonal antibody that binds the …

Monoclonal antibodies (mAbs) against the extracellular domain of the epidermal growth
factor receptor (EGFR) have been introduced for the treatment of metastatic colorectal …

EGF receptor (EGFR)-targeted monoclonal antibodies are effective in a subset of metastatic
colorectal cancers. Inevitably, all patients develop resistance, which occurs through …

We report a prostate cancer genome-wide association follow-on study. We discovered four
variants associated with susceptibility to prostate cancer in several European populations …

Through complementary application of SNP genotyping, whole-genome sequencing and
imputation in 38,384 Icelanders, we have discovered a previously unidentified sick sinus …

Only a small proportion of cancers result from familial cancer syndromes with Mendelian
inheritance. Nonfamilial,'sporadic'cancers, which represent most cancer cases, also have a …

Background Genetic and epigenetic profiling of glioblastomas has provided a
comprehensive list of altered cancer genes of which only O6-methylguanine …

Previously, we reported germline DNA variants associated with risk of urinary bladder
cancer (UBC) in Dutch and Icelandic subjects. Here we expanded the Icelandic sample set …

A recent systematic sequence analysis of well-annotated human protein coding genes or
consensus coding sequences led to the identification of 189 genes displaying somatic …

We tested 16 million SNPs, identified through whole-genome sequencing of 457 Icelanders,
for association with gout and serum uric acid levels. Genotypes were imputed into 41,675 …