Each of the four human IgG subclasses exhibits a unique profile of effector functions relevant
to the clearance and elimination of infecting microorganisms. The quantitative response …

Background: Common variable immune deficiency (CVID) is prone to under‐diagnosis and
may not reach relevant specialists until late in life. Morbidity is most commonly due to acute …

The molecular basis of X-linked recessive anhidrotic ectodermal dysplasia with
immunodeficiency (EDA-ID) has remained elusive. Here we report hypomorphic mutations …

The human peripheral B-cell compartment displays a large population of immunoglobulin M–
positive, immunoglobulin D–positive CD27+ (IgM+ IgD+ CD27+)“memory” B cells carrying a …

Following infection with intracellular pathogens like mycobacteria, listeria, toxoplasma and
leishmania, mononuclear phagocytes and related antigen-presenting cells (APC), ie …

The immunogenetic basis of severe infections caused by bacille Calmette-Guérin vaccine
and environmental mycobacteria in humans remains largely unknown. We describe 18 …

Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently
described combined immunodeficiency resulting from gain-of-function mutations in PIK3CD …

Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid
differentiation factor (MyD) 88 deficiencies impair Toll-like receptor (TLR)-and interleukin-1 …

Interleukin-12 receptor A1 (IL-12RA1) deficiency is the most common form of Mendelian
susceptibility to mycobacterial disease (MSMD). We undertook an international survey of …

Interferon-gamma receptor ligand-binding chain (IFN-gammaR1) or signaling chain (IFN-
gammaR2) deficiency, like interleukin 12 receptor beta1 chain (IL-12Rbeta1) deficiency …