MicroRNAs are noncoding RNAs of∼ 22 nucleotides that suppress translation of target
genes by binding to their mRNA and thus have a central role in gene regulation in health …

Background Circulating nucleic acids (CNAs) offer unique opportunities for early diagnosis
of clinical conditions. Here we show that microRNAs, a family of small non-coding regulatory …

Summary p53 is a potent tumor suppressor, whose biological effects are largely due to its
function as a transcriptional regulator. Here we report that, in addition to regulating the …

MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that is involved in
oncogenesis and shows remarkable tissue specificity. Their potential for tumor classification …

MicroRNAs (MIRs) are a novel group of conserved short∼ 22 nucleotide-long RNAs with
important roles in regulating gene expression. We have established a MIR-specific …

A recurring challenge for brain pathologists is to diagnose whether a brain malignancy is a
primary tumor or a metastasis from some other tissue. The accurate diagnosis of brain …

Background RNA interference is a gene regulatory mechanism that employs small RNA
molecules such as microRNA. Previous work has shown that HIV-1 produces TAR viral …

Background. Cancers of unknown primary origin (CUP) constitute 3%–5%(50,000 to 70,000
cases) of all newly diagnosed cancers per year in the United States. Including cancers of …

Abstract MicroRNAs (miRNAs) are∼ 22-nt long, non-coding RNAs that regulate gene
silencing. It is known that many human miRNAs are deregulated in numerous types of …

Aims The distinction between benign and malignant thyroid nodules has important
therapeutic implications. Our objective was to develop an assay that could classify …