User profiles for "author:J Burnie"

Jonathan Burnie

Harvard TH Chan School of Public Health
Verified email at hsph.harvard.edu
Cited by 108

Fungal heat-shock proteins in human disease

JP Burnie, TL Carter, SJ Hodgetts… - FEMS microbiology …, 2006 - academic.oup.com
Heat-shock proteins (hsps) have been identified as molecular chaperones conserved
between microbes and man and grouped by their molecular mass and high degree of amino …

A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in …

…, J Garbino, J Takala, L Drgona, J Burnie… - Clinical Infectious …, 2006 - academic.oup.com
Abstract Background. Mycograb (Neu Tec Pharma) is a human recombinant monoclonal
antibody against heat shock protein 90 that, in laboratory studies, was revealed to have …

[HTML][HTML] The incorporation of host proteins into the external HIV-1 envelope

J Burnie, C Guzzo - Viruses, 2019 - mdpi.com
The incorporation of biologically active host proteins into HIV-1 is a well-established
phenomenon, particularly due to the budding mechanism of viral egress in which viruses …

Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90

…, C Gregory, C Illidge, J Burnie - Antimicrobial agents …, 2003 - Am Soc Microbiol
ABSTRACT Mycograb (Neu Tec Pharma plc) is a human genetically recombinant antibody
against fungal heat shock protein 90 (HSP90). Antibody to HSP90 is closely associated with …

The role of hsp90 in fungal infection

R Matthews, J Burnie - Immunology today, 1992 - cell.com
The immunodominant antigens of many microbial pathogens are heat shock proteins (hsps).
In systemic candidal infections, a major target of protective antibody is an epitope shared …

Autoantibody to heat-shock protein 90 can mediate protection against systemic candidosis.

RC Matthews, JP Burnie, D Howat, T Rowland… - …, 1991 - ncbi.nlm.nih.gov
Epitope mapping shows that patients recovering from systemic infection with Candida
albicans produce antibodies against both fungal-specific and conserved epitopes of the heat …

Isolation of immunodominant antigens from sera of patients with systemic candidiasis and characterization of serological response to Candida albicans

RC Matthews, JP Burnie… - Journal of Clinical …, 1987 - Am Soc Microbiol
Candidal antigens were isolated by affinity chromatography from the sera of patients with
disseminated Candida albicans infections. The immunodominant 47-kilodalton (kDa) …

Outbreak of systemic Candida albicans in intensive care unit caused by cross infection.

JP Burnie, FC Odds, W Lee, C Webster… - Br Med J (Clin Res Ed), 1985 - bmj.com
The first documented outbreak of systemic candidosis shown to be due to cross infection
with a particular strain of Candida albicans is reported. Over nine months in an intensive …

Kitchens as a source of Aspergillus niger infection

KW Loudon, AP Coke, JP Burnie, AJ Shaw… - Journal of hospital …, 1996 - Elsevier
In this study we investigated the epidemiology of a cluster of cutaneous infections owing to
Aspergillus niger, which occurred in neutropenic patients in a bone marrow transplant unit …

Evaluation of Mycograb®, amphotericin B, caspofungin, and fluconazole in combination against Cryptococcus neoformans by checkerboard and time-kill …

L Nooney, RC Matthews, JP Burnie - Diagnostic microbiology and infectious …, 2005 - Elsevier
This article reported the identification of heat shock protein 90 (hsp90) homologues by
immunoblot in Cryptococcus neoformans. Mycograb®, a genetically recombinant antibody …