FERRITIN is the major iron storage protein in the body. Although it is found in all tissues
there is little quantitative information about its distribution. Measurements of non-heme iron …

Haptoglobin (Hp) is a plasma α2‐glycoprotein which binds free haemoglobin, thus
preventing oxidative damage. The complex is rapidly removed from the circulation by a …

Iron Metabolism Most of the iron in the human body is found in hemoglobin, the oxygen-
carrying protein of the red blood cell, and quantitatively, iron metabolism is largely …

The relationship between serum ferritin concentration and the amount of storage iron has
been studied in normal subjects. A high degree of correlation was demonstrated between …

The concentration of ferritin in serum gives a quantitative measure of the amount of storage
iron in normal subjects and those with iron deficiency or overload. The mean level in normal …

People with genetic haemochromatosis (GH) accumulate iron from excessive dietary
absorption. In populations of northern European origin, over 90% of patients are …

The FMS gene encodes the functional cell surface receptor for colony-stimulating factor 1,
the macrophage-and monocyte-specific growth factor. Codons 969 and 301 have been …

The iron storage protein ferritin is found in all cells of the body as multiple isoferritins
composed of 24 sub units of two types. The structure is well understood from increasingly …

The description by Ramsay in 1957 of a practical way of determining the total iron binding
capacity of serum (a measure of transferrin concentration) provided a diagnostic test for both …

Background Sporadic porphyria cutanea tarda is a skin disease associated with hepatic
siderosis. Depletion of iron stores by phlebotomy is curative. The role of haemochromatosis …