Centrosome amplification: a quantifiable cancer cell trait with prognostic value in solid malignancies
Numerical and/or structural centrosome amplification (CA) is a hallmark of cancers that is
often associated with the aberrant tumor karyotypes and poor clinical outcomes …
often associated with the aberrant tumor karyotypes and poor clinical outcomes …
Molecular complexity of lymphovascular invasion: the role of cell migration in breast cancer as a prototype
Lymphovascular invasion (LVI) is associated with poor outcome in breast cancer (BC);
however, its underlying mechanisms remain ill-defined. LVI in BC develops through complex …
however, its underlying mechanisms remain ill-defined. LVI in BC develops through complex …
[HTML][HTML] Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer
AE Harris, VM Metzler, J Lothion-Roy… - Frontiers in …, 2022 - frontiersin.org
Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-
induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (eg …
induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (eg …
[HTML][HTML] Predictors of pathological complete response to neoadjuvant treatment and changes to post-neoadjuvant HER2 status in HER2-positive invasive breast …
The response of human epidermal growth factor receptor2 (HER2)-positive breast cancer
(BC) patients to anti-HER2 targeted therapy is significant. However, the response is not …
(BC) patients to anti-HER2 targeted therapy is significant. However, the response is not …
[HTML][HTML] Prognostic significance of tumor-infiltrating lymphocytes in ductal carcinoma in situ of the breast
Tumor-infiltrating lymphocytes (TILs) provide prognostic value in invasive breast cancer and
guidelines for their assessment have been published. This study aims to evaluate:(a) …
guidelines for their assessment have been published. This study aims to evaluate:(a) …
Overexpression of the cancer stem cell marker CD133 confers a poor prognosis in invasive breast cancer
C Joseph, M Arshad, S Kurozomi, M Althobiti… - Breast Cancer Research …, 2019 - Springer
Purpose CD133/prominin 1 is a cancer stem cell marker associated with cancer progression
and patient outcome in a variety of solid tumours, but its role in invasive breast cancer (BC) …
and patient outcome in a variety of solid tumours, but its role in invasive breast cancer (BC) …
Refining the definition of HER2‐low class in invasive breast cancer
Background Emerging evidence indicates that breast cancer (BC) patients whose tumours
express HER2 protein without HER2 gene amplification (HER2‐low), can benefit from …
express HER2 protein without HER2 gene amplification (HER2‐low), can benefit from …
[HTML][HTML] A whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk
Background Breast ductal carcinoma in situ (DCIS) represent approximately 20% of screen-
detected breast cancers. The overall risk for DCIS patients treated with breast-conserving …
detected breast cancers. The overall risk for DCIS patients treated with breast-conserving …
[HTML][HTML] The prognostic significance of interferon-stimulated gene 15 (ISG15) in invasive breast cancer
Background Lymphovascular invasion (LVI) is a prognostic factor in early-stage invasive
breast cancer (BC). Through bioinformatics, data analyses of multiple BC cohorts revealed …
breast cancer (BC). Through bioinformatics, data analyses of multiple BC cohorts revealed …
Breast cancer histologic grading using digital microscopy: concordance and outcome association
Aims Virtual microscopy utilising digital whole slide imaging (WSI) is increasingly used in
breast pathology. Histologic grade is one of the strongest prognostic factors in breast cancer …
breast pathology. Histologic grade is one of the strongest prognostic factors in breast cancer …